HMGB1 and osteosarcoma: After treated with a chemical library in osteosarcoma U2OS cells, higher levels of p-eIF2a, calreticulin (CALR), and HMGB1 were detected in U2OS cells treated with Paclitaxel/Docetaxel than in U2OS cells treated with Fluorouracil/Capecitabine (24).