CD8A and neoplasm: In particular, TANs were polarized into 2 subtypes (N1 and N2) based on a variety of environmental factors including cytokines and chemokines in the TME, and the N1 TANs exhibited tumor suppression via activation of CD8+ T cells, while the N2 neutrophils stimulated tumor growth, invasion, metastasis, and angiogenesis (57).