Although there is some evidence suggesting Kir4.1 expression increased in a pilocarpine model of temporal lobe epilepsy (Nagao et al., 2013) and a mouse model of Dravet syndrome (Miljanovic et al., 2021), most studies suggest the opposite, that astrocyte Kir4.1 channel expression is diminished in epilepsy (Kinboshi et al., 2020; Ohno et al., 2021). The gene discussed is KCNJ10; the disease is epilepsy.