This is of interest because BDNF is a potent modulator of epileptogenesis; BDNF expression reportedly increased in the brains of epileptic patients and animal models of epilepsy (Jankowsky and Patterson, 2001), whereas disruption of BDNF/TrkB signaling suppressed seizure activity in epileptic mouse models (Kokaia et al., 1995; Hagihara et al., 2005; Liu et al., 2013). Here, BDNF is linked to epilepsy.