ERBB2 expression was found to be increased in both pulmonary fibrosis patients and animal models, and the activation of phosphorylated ERBB2 in normal lung fibroblasts may be the cause of fibroblast invasion and pulmonary fibrosis, while antagonizing HER2 can weaken the invasion ability of fibroblasts and improve pulmonary fibrosis (Liu et al., 2022; Li et al., 2011). The gene discussed is ERBB2; the disease is pulmonary fibrosis.