IDH2 and neoplasm: Survival is influenced by patient-specific factors such as age and performance status, and tumor-related factors including anatomical location, size of enhancing tumor, and molecular characteristics such as isocitrate dehydrogenase mutation (IDH) and methylation of the O (Maldaun et al., 2004)-methylguanine-DNA methyltransferase promoter (pMGMT) (Walid, 2008).