The bubble diagram revealed that the extent of CXCL16/CXCR6 signaling was the highest between LSEC and NKT cells, suggesting that the mechanism of LSEC using CXCL16 as a messenger to recruit NKT cells may similarly present in human HCC (Figure 3C). The gene discussed is CXCL16; the disease is hepatocellular carcinoma.