To this end, we have investigated the IL-27/pSTAT1/T-bet, and the PI3K/AKT pathways that have been reported to connect PD-1 and TIM-3 in tumor-bearing mice and patients with head and neck squamous cell carcinomas (53, 54), but we have not found any evidence of PD-1/TIM-3 cross-talk via these pathways in BM MM Vγ9Vδ2 T cells. Here, AKT1 is linked to head and neck squamous cell carcinoma.