Figure 3A shows the expression of selected TCR-associated molecules in purified BM γδ T cells from one representative Ctrl and MM patient on day 0 and after ZA-stimulation (day 7). As reported above, both Vδ1 and Vγ9Vδ2 cells are represented in freshly purified γδ T cells (day 0), whereas Vγ9Vδ2 T cells are predominant on day 7 and they are the only γδ T-cell subset engaged by ZA (Supplemental Figure 1). Pooled data are shown in Figure 3B showing that BM MM Vγ9Vδ2 T cells had significantly lower pAKT, higher PTEN, and lower pSTAT-1 expression on day 7 compared to BM Ctrl Vγ9Vδ2 T cells. Here, PTEN is linked to Miyoshi myopathy.