In our point of view, the illustrated capacity of Salmonella to broaden the response to PD-L1 inhibitors is, in part, mediated by its ability to increase the infiltration of intratumoral T cells and its potential to induce direct tumor killing and release tumor-associated antigens leading to the induction of antigen-presenting cells, antigen cross-presentation and activation of T cells. This evidence concerns the gene CD274 and neoplasm.