The increased infiltration of CD8+ TILs cells into tumor tissues (as observed in immunohistochemical staining) is attributed to the increased infiltration of CD45+ immune cells that include similar percentages of CD8+ T cells in the control and combination-treated groups and this is demonstrated as an increase in the percentage of these cells out of total tumor tissue (Figure 9G). The gene discussed is PTPRC; the disease is neoplasm.