PRGs with consistent enhanced expression and association with poor survival in cancers included GSDMC in BRCA, KIRC, LIHC, PAAD, UVM and KICH; DFNA5 (GSDME) in COAD, STAD, UCEC, HNSC, KIRC; and AIM2 in KIRP, KIRC, UVM, and PAAD. The gene discussed is GSDME; the disease is cancer.