Overall pan-cancer expression of each gene is illustrated in Figure 1A indicating a strong pan-cancer expression of GSDMD, PYCARD12, GPX4, DHX9 and DDX3X. Comparative expression levels for main gasdermins (GSDMB, GSDME, AIM2) and inflammasomes (NLRP1, NLRP3, and NLRC4) could also be observed. The gene discussed is GSDME; the disease is cancer.