Significantly upregulated PRGs included PYCARD in 12 cancers; GSDMB in 10 cancers; IL18 in 9 cancers; GSDMD, CASP8, GZMB, and GPX4 in 8 cancers; AIM2 and CASP6 in 7 cancers; GZMA in 6 cancers; GSDME, CASP4 and DHX9 in 5 cancers; GSDMA and GSDMC in 4 cancers (Figure 1C). This evidence concerns the gene CASP8 and cancer.