The changes of Il12rb1, Cd40, Il12rb2, Cxcl16, Ccl9, Ifnar2, Ltb, Csf1r, Il18rap, Il18r1, Il2ra, Bmp2, Il1b, Pdgfc, Csf3r, Cxcl9, Ccr9, Cd27, Il21r, Il4ra, Il2rg, Pdgfd, Il10ra, Crlf2, Ccl5, Ccl2, Inhbb, Il18, Cxcr6, Ccr2, Cxcr3, Cx3cr1, Cxcl2, Xcr1, Il2rb, Csf2rb, Csf2rb2, Ccl28, and Ccr5 mRNAs were enriched into the cytokine–cytokine receptor interaction; and previous studies have demonstrated that the chemokine receptor gene CXCR6 was highly expressed in +CPI colitis T cells and a variety of human cancer cells (Luoma et al., 2020). This evidence concerns the gene IL21R and cancer.