CASP3 and neoplasm: Granzyme B (GzmB) and Granzyme A (GzmA) are apoptotic proteinase-like serine proteases that can activate caspase-3 and caspase-8 and be transferred to target cells by cytotoxic lymphocytes to trigger cell apoptosis, pyroptosis, and kill virus-infected cells and tumor cells (Jiang et al., 2020; Zhang et al., 2020).