TP53 and cancer: The KEGG analysis of DEGs showed that the pathways of Herpes simplex virus 1 infection, HIF-1 signaling pathway, NF-kappaB signaling pathway, TNF-signaling pathway, ribosome, apoptosis, legionellosis, small cell lung cancer, p53 signaling pathway, platinum drug, cellular senescence, toxoplasmosis, Epstein–Barr virus infection, human T-cell leukemia virus 1 infection, endocytosis, microRNAs in cancer, FoxO signaling pathway, valine, leucine and isoleucine degradation, rheumatoid arthritis, fluid shear stress, and atherosclerosis were the top enriched pathways (Figures 6A, S7B, C).