TRPC1 and cardiovascular disorder: 2019). A variety of drugs have been successfully developed for clinical application from Salvia miltiorrhizae. They have been used to treat cardiovascular system diseases (Orgah et al. 2020), skin diseases (Hu and Ren 1998), liver and kidney diseases (Cao et al. 2017), etc., and have achieved good effects. In this study, we found the RosA from the Salvia miltiorrhizae acting on the novel target TRPC1 based on the ‘homology modelling–virtual screening–molecular docking–affinity assay–activity evaluation’ method.