Gong et al. [41] reported that FASN regulated HIF1α expression in HCC cells, while the results of our study demonstrated for the first time that in HCC-SR cells, FASN bound to and promoted nuclear translocation of HIF1α, while inhibiting ubiquitination and proteasomal degradation, consistent with previous reports of the roles of HIF1α in tumor progression and drug resistance [42–44]. The gene discussed is FASN; the disease is hepatocellular carcinoma.