Moreover, knockdown of FASN significantly increased lipid peroxidation and MDA levels, and HIF1α reversed this effect in sorafenib-exposed HCC-SR cells, indicating that FASN upregulated promoted resistance of HCC-SR cells to sorafenib-mediated ferroptosis via HIF1α (Fig. S3A–B). Here, FASN is linked to hepatocellular carcinoma.