Hyperinsulinemia is associated with decreased expression levels of glycodelin and insulin-like growth factor binding protein 1 (IGFBP-1), which are responsible for the immune response of the mother’s immune system towards the implanted embryo and facilitation of the adhesion process of blastocysts, respectively [9, 26, 27]. This evidence concerns the gene IGFBP1 and Hyperinsulinemia.