After OVs infect tumor cells, they promote the release of cytokines (e.g., GM-CSF, TNF-α, IFN) and TAA from tumor cells, attracting many APCs to the tumor injection site, which in turn stimulates the production of CD8+ T cells and increases their infiltration into the TME, preparing the ICIs for action. The gene discussed is CD8A; the disease is neoplasm.