(2) Tumor-suppressive microenvironment reversal: the TME is the soil for tumor survival and contains a plethora of immunosuppressive cells, such as immunomodulatory T cells (Tregs), and myelogenous suppressor cells (MDSCs), immunosuppressive cytokines, and molecules such as IL-10 and PD-L1. Here, CD274 is linked to neoplasm.