This study is the first time the effect of ATP2B4 polymorphisms on erythrocytes and on malaria pathogenesis from people living in a malaria endemic region has been investigated Here the effects of three common ATP2B4 genotype groups defined by the tagging SNP rs1541252 on in vitro P. falciparum growth, adhesion, invasion are reported. The gene discussed is ATP2B4; the disease is malaria.