MYOCD and SRF complex increases expression of VSMC differentiation markers by binding the CArG box of target promoters to form a MYOCD-SRF-CArG box complex (Chen et al. 2002; Wang et al. 2003), overexpression of MYOCD up-regulates the expression of multiple contractile genes and prevents atherosclerotic lesions. The gene discussed is SRF; the disease is Atherosclerotic lesion.