Besides, other transcription factors, such as growth arrest-specific homeobox (GAX) (Markmann et al. 2003) and Nuclear factor of activated T cells 5 (NFAT5) (Halterman et al. 2011), are also considered to alleviate the development of atherosclerotic lesions, loss of which is a major factor that contributes to atherosclerosis. The gene discussed is NFAT5; the disease is atherosclerosis.