To assess in vivo impacts of macrophages pre-conditioned with exosomal LINC00963 on tumor progression in vivo, we firstly treated macrophages with exosomes isolated from A549 cells, or isolated from A549 cells with LINC00963 overexpression or knock down, and then injected A549 cells alone (control) or with exosomes-treated macrophages into immunocompromised mice. The gene discussed is LINC00963; the disease is neoplasm.