Compared with patients with strict-normal thyroid function, those with low thyroid function were more likely to be older, females; with higher levels of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, AST, fasting glucose; with lower levels of ALT, gamma-glutamyl transpeptidase (GGT), platelets count, albumin; and a higher prevalence of T2DM and hypertension. The gene discussed is GPT; the disease is hypertensive disorder.