NOTCH2 and B-cell chronic lymphocytic leukemia: Among the most frequently mutated CCGs in primary EBV + DLBCLs, we detected recurrent mutations of NOTCH2 and NOTCH1. NOTCH mutations frequently occur in splenic marginal zone lymphoma and chronic lymphocytic leukemia but were also reported in subsets of DLBCLs NOS and EBV + DLBCLs [10, 11, 49–51].