OTUD7A and epilepsy: We identified 10 high-confidence category 1, 2 or syndromic SFARI genes in the list of 44 OTUD7A BioID2 hits (Fig. 3b and Supplementary Table 5) (22.7%; p = 7.01 × 10–5, Fisher’s exact test; OR = 5.4), as well as 4 high-confidence epilepsy-associated genes [63] (Fig. 3b and Supplementary Table 5) (9.1%; p = 2.45 × 10–4, Fisher’s exact test; OR = 14.83), suggesting that OTUD7A may be a component of known ASD and epilepsy-associated pathways.