Enrichment analysis with the DEGs demonstrated overrepresentation of KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways for autoimmune diseases such as ‘rheumatoid arthritis’ and ‘inflammatory bowel disease’ (Fig. 2f), which supported the proinflammatory nature of the IL1A-expressing TH17 cell subset. Here, IL1A is linked to inflammatory bowel disease.