Both weight gain35 and alopecia36, for example, are reported among some DMPA users, and our analysis of differential gene expression showed that the CRTC (CREB-regulated transcription coactivator 3) gene, which plays a role in obesity35 and PRMT9 (Protein Arginine Methyltransferase 9) gene that has been associated with mandibulofacial dysostosis with alopecia were both up-regulated. The gene discussed is CALR; the disease is mandibulofacial dysostosis.