These upregulated genes (Cdkn1a, Eda2r and Phlda3), are known for their role in cell cycle arrest, apoptosis and tumor suppression, while the most downregulated genes (Hba-a2, Serpina9, and Ms4a1) are associated with hemoglobin synthesis, mitochondrial function and B cell differentiation (Table 1)34–43. This evidence concerns the gene CDKN1A and neoplasm.