This vaccine boosts CD8+ T cells while decreases T regulatory cells in mice with CT26 tumor.323 Heat shock proteins (HSPs), like HSP70, have also been complexed with synthetic peptides derived from tumor-specific neoantigens to enhance the presentation and recognition of antigens, which are widely used for treating advanced tumors resistant to conventional therapies (NCT02992977, NCT03673020).324,325 Nanoparticle formation is another technique for improving the immunogenicity of peptide vaccines. The gene discussed is CD8A; the disease is neoplasm.