CAR-T cells with an scFv that recognizes the oncogene nucleophosmin (NPM1c) epitope-HLA-A2 complex demonstrated strong cytotoxicity against NPM1c+HLA-A2+ leukemia cells and AML blasts with no or minimal on-target/off-tumor toxicity.336,376,426. The gene discussed is NPM1; the disease is acute myeloid leukemia.