Retrospective analysis of the infusion product has shown that the CD4+ T-helper 1 cells were reactive to an ERBB2IP mutation, suggesting a potential function of neoantigen-specific CD4+ T cells in the control of a metastatic epithelial cancer.386 TILs from individuals with metastatic gastrointestinal cancers have CD4+ and/or CD8+ T cells that recognize neoantigens resulting from somatic tumor mutations. The gene discussed is CD4; the disease is neoplasm.