In addition, co-culturing autologous PBMCs with tumor organoids produced personalized tumor-reactive CD8+ T lymphocytes that significantly reduced the growth of tumors.405,510 Although further improvements are required to conserve TME, including myeloid and stromal components, the organoid model may offer a better in vitro opportunity for neoantigen presentation and recognition by T cells. Here, CD8A is linked to neoplasm.