TP53 and neoplasm: While TP53 mutations are dominant in HG-SOC cells, it is now commonly accepted that stromal elements, including EC and activated fibroblasts, do not harbor genetic alterations in TP53. However, the canonical p53 functionality in such stromal components is frequently compromised, switching from tumor-suppressive to tumor-supportive, rendering these cells gradually more aggressive [45, 51, 52].