TRAF6 and esophageal squamous cell carcinoma: Yao et al. found that knocking out the TRAF6 gene could prevent the metastasis of esophageal squamous cell carcinoma cells in vivo or in vitro, studied the mechanism of metastasis, and enhanced that it was the result of ERK phosphorylation caused by the binding of the N-terminal of TRAF6 to Ras.