TRAF6 and colorectal cancer: In SW480 cells constructed with KO-TRAF6 by the CRISPR-Cas9 system (Fig. 5q), it was found that the necroptosis of KO-TRAF6 in colorectal cancer cells was significantly higher than that of the mock control group (Fig. 5r) while inhibiting cell proliferation and clonal colony formation (Fig. 5s, t).