The Wnt signalling pathway is a major pathway responsible for human tooth agenesis.127,128 Different combinations of sequence variants in Wnt-related genes (such as WNT10A, WNT10B, LRP6, AXIN2, KREMEN1, etc.)lead to various patterns of missing teeth.129 Wnt10A mutations preferentially affect the permanent dentition instead of the deciduous dentition, indicating that the role of Wnt10A may vary between the development of deciduous and permanent teeth.130 Wnt10B mutations also tend to interfere with the development of permanent teeth, especially the lateral incisors.131. This evidence concerns the gene AXIN2 and tooth agenesis.