Compared with the CC genotype (lactase deficiency), CT/TT genotype (lactase persistence) was associated with a higher risk of CHD (CT/TT vs. CC: HR = 1.27; 95% CI: 1.03, 1.55) and CVD (HR = 1.22; 95% CI: 1.05, 1.42), but was not significantly associated with risks of ischemic stroke and CVD mortality. Here, LCT is linked to ischemic stroke.