SMN1 and proximal spinal muscular atrophy: For this purpose, we prepared two pairs of isogenic iPSC clones with a doxycycline-inducible MYOD1 expression construct: first, a control 201B7 iPSC line and its SMN-knockdown counterpart (B7-M and B7-MSMNKD, respectively); and second, an SMA patient–derived iPSC line (Yoshida et al, 2015) and the same line but with SMN supplementation (SMA-M and SMA-MOE, respectively).