On the other hand, the tumor microenvironment plays an essential role in cancer cell migration and invasion, and cancer cells can also induce CAF differentiation to remodel the ECM by secreting TGF-β and extracellular vesicles containing miRNA192/215 to inhibit CAV1 expression and activate the TGF-β/Smad pathway in fibroblasts[44]. The gene discussed is TGFB1; the disease is cancer.