,18,35,36 Here, we assessed the sensitivity of BA.1 and BA.4 to nAbs and ADCC potential as measured by FcγRIIIa signaling (but hereafter referred to as ADCC) elicited by infections caused by D614G, Beta, Delta, or BA.1 (responsible for the first four waves in South Africa) in vaccinated and unvaccinated individuals. The gene discussed is FCGR3A; the disease is infection.