IGF1 and familial hyperaldosteronism: Of note, these findings are consistent with the ability of IGF-1 to upregulate expression of the antioxidant enzyme glutathione peroxidase in cultured ECs (67) and to downregulate 12/15-lipoxygenase levels in murine plaques (68), suggesting that these mechanisms may be relevant to the effects of IGF-1 in the FH pig model.