Because of the early lethality of caspase-8 single-KO mice, 5xFAD Casp8–/–Ripk3–/– (i.e., double KO [DKO]) mice were compared with age- and sex-matched 5xFAD and 5xFAD Ripk3–/– littermate controls to evaluate the role of caspase-8 in AD pathogenesis. This evidence concerns the gene RIPK3 and Alzheimer disease.