Indeed, in 2 previous reports of human patients with microphthalmia, 1 of whom was genetically characterized to show a 3q27 deletion spanning SOX2, MRI showed olfactory tract hypoplasia/aplasia consistent with disordered olfactory morphogenesis, thus lending further support to the role of SOX2 in olfaction (31, 32). Here, SOX2 is linked to microphthalmia.