NFE2L2 and neoplasm: On univariate Cox proportional hazard modeling, patients with TMB-high tumors had improved PFS (HR, 0.45; 95% CI, 0.21-0.90; P = .03), while other tumor and patient factors, including DDR and KEAP1/NFE2L2 alteration status, were not significantly associated with PFS (eTable 3 in Supplement 1).