The Further Cardiovascular Outcomes Research with proprotein convertase subtilisin/kexin type 9 (PCSK9) Inhibition in Patients with Elevated Risk (FOURIER) trial showed safety and efficacy of adding evolocumab to a statin in ASCVD patients with LDL-C levels > 70 mg/dL on optimized lipid-lowering therapy [16]. Here, PCSK9 is linked to atherosclerosis.