Also, and more plausible, counter‐regulatory hormones released during hypoglycaemia can activate the carotid bodies with strong evidence in rats that adrenaline released during hypoglycaemia is the principal mediator of carotid body excitation in response to insulin‐induced hypoglycaemia (Thompson et al., 2016), critical to hyperpnoea and acid–base balance. The gene discussed is INS; the disease is Hypoglycemia.