IL27 and infection: Taking into account the distinct effects of IL-27 on HIV-1 replication when added immediately after infection (day 0) or 4 days postinfection (dpi) and that up to 60% of the HIV-1 infection in culture is derived from cell-to-cell transmission (28), we pondered wether such divergence could be due to the fact that, when added at 4 dpi, IL-27 would act in a culture containing a larger number of infected cells and, consequently, in an enlarged area of contact between infected and uninfected cells.