The first one21 reported that treatment of p48Cre; KrasG12D (KC) mice with the TLR7 agonist ssRNA40 strongly accelerated tumor progression, while TLR7 inhibition with IRS‐954 was able to block caerulein‐induced inflammation‐mediated tumor progression in KC mice. The gene discussed is TLR7; the disease is keratoconus.