However, given the complex interplay of different types of immune and stroma cells in the tumor microenvironment and the wide range of subtypes and functional states of different immune cell populations, much more in‐depth work will be required to precisely dissect the roles of TLR7 and its ligands in different populations of epithelial and stromal cells and to understand their relative contributions to the promotion or attenuation of tumor progression in pancreatic cancer. The gene discussed is TLR7; the disease is familial pancreatic carcinoma.