ABCC2 and cholestasis: In mice, cholestasis is milder, as mouse hydrophilic tetra (3α-, 6α-, 7α- and 12α-) hydroxylated bile acids (Figure 2) are also excreted through the multidrug resistance protein 1a et 1b (MDR1a/1b) and the multidrug resistance associated-protein 2 (MRP2) [47–49].