Eight-six out of 107 (81.9%) patients continued with the same Tac dosage after 1 year and the dosage was decreased in six patients (5.7%), increased in 11 patients (10.5%) and two (1.9%) patients were withdrawn from PR-Tac: the first patient due to frequent episodes of hypertension, diarrhea and vertigo and reconverted to IR-Tac; the second one due to de novo intestinal adenocarcinoma and subsequently switched to mTOR-inhibitor monotherapy. This evidence concerns the gene MTOR and hypertensive disorder.