MAPT and early-onset autosomal dominant Alzheimer disease: The mislocalization of NUP98 along the nuclear envelope and in the cytoplasm in the frontal cortex of primary tauopathies (Fig. 1) is consistent with the previous similar observations in Alzheimer’s disease.7 The altered localization of NUP98 along the nuclear envelope leading to a non-uniform distribution of NUP98 around the nucleus is seen in FTLD-tau, CBD and PSP (Fig. 2A).