PIK3C3 and osteosarcoma: Similarly, the Tripartite Motif-Containing Protein 28 (TRIM28) with the SUMO E3 ligase activity binds to the lncRNA PVT-1 and sumoylates the phosphatidylinositol 3-kinase catalytic subunit type 3 (Vps34), which enhances the ubiquitination and degradation of the tumor suppressor complex 2 (TSC2), thus contributing to stem cell phenotypes such as invasion in osteosarcoma (Tsang et al., 2022).