In this sense, key factors in the vasculopathy and inflammatory response include vascular cell adhesion molecule-1 (VCAM-1), one of the main responsibles of the firm adhesion of leukocytes to the endothelium (Dessein et al., 2005; Navarro-Hernández et al., 2009; Murdaca et al., 2012; Steyers and Miller, 2014; Wang et al., 2015; Kong et al., 2018), and the monocyte chemoattractant protein-1 (MCP-1), a chemokine that regulates the endothelial transmigration of monocyte (Hayashida et al., 2001; Rantapää-Dahlqvist et al., 2007; Deshmane et al., 2009; Dessein et al., 2013; Yang et al., 2016). This evidence concerns the gene CCL2 and vascular disorder.