Proinflammatory cytokines interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) that are strongly expressed in the vascular niche in response to injury suppressed COUP-TF2 expression, while COUP-TF2 ablation exacerbated influenza lung injury (Zhao et al., 2020). The gene discussed is NR2F2; the disease is influenza.