Cx43 plays an important role in coordinating metabolism and signaling between interconnected cells and promotes carcinogenesis in urinary bladder carcinoma (Wang et al., 2010; Abounit and Zurzolo, 2012; Poyet et al., 2015; Ariazi et al., 2017; Roehlecke and Schmidt, 2020). This evidence concerns the gene GJA1 and urinary bladder carcinoma.