TP53 and neoplasm: As previously stated, proteinopathies are often associated with neurodegenerative and aging-related diseases (Stefani and Dobson, 2003); nevertheless, p53, the most well-known tumor suppressor, was found to form amyloid fibrils and undergo aggregation in diverse types of cancer (Silva et al., 2013), indicating that cancer might also be considered a protein aggregation disease.