PTEN and cancer: For instance, in several types of tumors at MAM apoptosis-related proteins such as: Bax, Bak, Bcl-2, Bcl-xL (Scorrano et al., 2003; Chami et al., 2004), and other proteins as: PML (Giorgi et al., 2010; Missiroli et al., 2016), p53 (Giorgi et al., 2015, PTEN (Bononi et al., 2013), kRAS (Pierro et al., 2014), and mTORC2/akt (Marchi et al., 2008; Marchi et al., 2012; Betz et al., 2013), were found to be involved in the regulation of Ca+-dependent cancer cell survival and propagation.