(86) revealed a decrease in Fibroblast-5s (Sox9, Spp1, Nt5e, cspg4, and clip), an increase in Fibroblast-2s (Cd34, Ly6a, Pdgfra, Thy1, and Cd44), and a Cxcl12-secreting CAF phenotype of Fibroblast-1s (with upregulation of Cxcl12, Kitl, and Angpt1) in mice BM with AML. This evidence concerns the gene CXCL12 and acute myeloid leukemia.