CASP1 plays an important role in the classical pathway of pyroptosis, a cell death pathway involved in the pathology of acute cerebral ischemia, and studies have shown that inhibition of CASP1 activation in IS can rescue infarct volume, promote motor recovery, and improve behavioral outcomes in mouse stroke models (Li et al., 2020; Ma et al., 2020). This evidence concerns the gene CASP1 and stroke disorder.