KEGG analysis showed that many related pathways were significantly enriched, including RIG-I-like receiver signaling pathway, NF kappa B signaling pathway, Influenza A. In addition, it could be seen from the correlation analysis with AEC2 (SARS CoV-2 receptor) that there was a positive correlation between the expression of DDX58 and ACE2 in many cancers (Supplementary Figure S2). Here, RIGI is linked to cancer.