In conclusion, the expression level of DDX58 was significantly different in pan carcinoma.Turning RIG-I Sensor Activation Against Cancer had been used in clinical trails (Iurescia et al., 2020).And it had been proved that SARS CoV-2 M protein could inhibit the expression of IFNb and interferon stimulated genes induced by RIG-1(Sui et al., 2021). The gene discussed is RIGI; the disease is cancer.